Annales françaises d'anesthèsie et de rèanimation
-
Ann Fr Anesth Reanim · Jul 2003
Case Reports[Vasodilatory septic shock refractory to catecholamines: is there a role for terlipressin?].
We report two patients in vasodilatory septic shock refractory to catecholamines in which a continuous infusion of terlipressin was associated with a dramatic increase in systemic arterial blood pressure and short-term survival. Low doses of terlipressin were sufficient in both cases (0.01-0.0 mg h(-1)) to restore blood pressure by increase of systemic vascular resistances. The haemodynamic response was immediate, long-acting, dose-dependent and reversible in a few hours when the drug administration was stopped. ⋯ Terlipressin simultaneously induced vasoconstriction within the cutaneous vascular territory, leading to local skin necrosis. The splanchnic vascular territory seemed to be constricted in the same way. Further studies are needed to better understand and precise the role of terlipressin in the treatment of vasodilatory septic shock refractory to catecholamines.
-
Ann Fr Anesth Reanim · Jul 2003
Case Reports[Lepirudin during cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia].
Lepirudin is an alternative anticoagulant therapy in heparin-induced thrombocytopenia (HIT) during cardiopulmonary bypass (CPB). We report a case of a female patient with HIT referred for aortocoronary bypass graft despite persistence of antibodies to platelet factor 4-heparin complexes. Anticoagulation management is described. ⋯ Total lepirudin administration was 44 mg. No haemorrhagic or thrombotic events were observed during surgical procedure and postoperative course. Despite lepirudin administration is not yet clearly precise for CPB procedure, its use seems adapted and safe in subjects without renal insufficiency but requiring precise coordination for anaesthesiological, surgical and biological teams.
-
We report the case of an 11 months old boy who felt from 3 m high. He had an isolated brain injury with contusion and bleeding in the right frontal lobe. ⋯ This peritoneal fluid was transudative ascitic fluid which appeared to be mediated by beta-sympathetic hyperactivity of central origin. Sequential echography showed progressive improvement and disappearance of the ascite on 19th day post trauma.