Annales françaises d'anesthèsie et de rèanimation
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Ann Fr Anesth Reanim · Jun 2002
Review[Sedation induced by midazolam in intensive care: pharmacologic and pharmacokinetic aspects].
Review on midazolam in order to optimize drug utilisation and therapeutic monitoring. ⋯ According to midazolam pharmacokinetic and pharmacodynamic variability, an individual dosage adjustment is essential for long-term sedation. Target controlled sedation could be a mean to limit the variability and to reach quickly the pharmacodynamic effect.
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Ann Fr Anesth Reanim · Jun 2002
Clinical Trial[Laparoscopic adrenalectomy for pheochromocytoma. Perioperative blockade with urapidil].
To investigate the effects of coeliosurgery by catecholamine assays and the use of urapidil in the management of phaeochromocytoma. ⋯ Perioperative alpha 1 blockade by urapidil enables an effective and easy control of acute preoperative haemodynamic changes.
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Factor X deficiency is one of the rarest inherited coagulation disorders. It is an autosomal recessive inherited disease. In its homozygous form factor X deficiency has an estimated prevalence of 1: 500,000. ⋯ She delivered a healthy baby at 33 weeks of gestation. No episode of abnormal bleeding was observed. Therefore in this case, prophylactic therapy using prothrombin complex concentrates during labour and delivery did prevent severe haemorrhages.
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The authors report the case of an 18-year-old man with polytrauma, who died at the third day of its accident from brain death and who presented during his stay in the intensive care unit, a deep hypophosphatemia. Two physiopathologic mechanisms were presumed: increase of renal losses and intracellular transfer of phosphorus. Consequences, as well as the indications and the therapeutic modalities of hypophosphatemia are discussed.