Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie
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Biomed. Pharmacother. · Apr 2019
Decitabine enhances tumor recognition by T cells through upregulating the MAGE-A3 expression in esophageal carcinoma.
Cancer testis (CT) antigens are expressed in various types of tumors and represent the potential targets for T cell-based immunotherapy. Analysis of CT gene expression and DNA methylation have indicated that certain CT genes are epigenetically regulated and studies have confirmed that certain CT antigens are regulated by DNA methylation. In this study, we explored the epigenetic regulation of MAGE-A3 and improved the clinical outcome of MAGE-A3-specific T cell therapy in esophageal squamous cell carcinoma (ESCC). ⋯ In the tumor cell-xenograft mouse model and ELISPOT assays, DAC increased the expression of MAGE-A3 and T cell mediated tumor clearance in ESCC as well. Notably, the proportions of MAGE-A3-responsive T cells were elevated in DAC-treated patients with MDS, indicating DAC dismissed the epigenetic inhibition of MAGE-A3. DAC would probably improve the clinical outcome of MAGE-A3-specific T cell therapy by augmenting the expression of target gene.
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Biomed. Pharmacother. · Apr 2019
Finite element analysis of different internal fixation methods for the treatment of Pauwels type III femoral neck fracture.
To compare the bifomechanical advantages and disadvantages of different internal fixation methods for the treatment of Pauwels type III femoral neck fractures. ⋯ The "F" shaped cannulated screw technique is capable of eliminating the torsional stress and shear stress while maintaining the axial compressive stress at the fracture end. Besides, the medial support plate can effectively resist the shearing force of the Pauwels III femoral neck fracture and create an excellent mechanical environment for fracture healing. Thus, for the Pauwels III femoral neck fracture, the use of "F" shaped cannulated screws combined with medial plate internal fixation are recommended.
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Biomed. Pharmacother. · Apr 2019
Tanshinone IIA attenuates sepsis-induced immunosuppression and improves survival rate in a mice peritonitis model.
The importance of sepsis-induced immunosuppression and its contribution to mortality has recently emerged. In this study we examined the effects of Tanshinone II-A (TSN), a widely used traditional Chinese medicine, on immunosuppression in experimental peritonitis induced septic mice. ⋯ Overall, our data suggest that TSN exerts immune modulatory effect and might be a useful strategy to ameliorate immunosuppression in polymicrobial sepsis.