Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie
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Biomed. Pharmacother. · Jan 2021
Randomized Controlled Trial Multicenter StudyTocilizumab combined with favipiravir in the treatment of COVID-19: A multicenter trial in a small sample size.
Since December 2019, COVID-19 has spread to almost every corner of the world. In theory, tocilizumab and favipiravir are considered to be reliable drugs for the treatment of COVID-19 with elevated IL-6. We aimed to assess the efficacy and safety of tocilizumab combined with favipiravir in patients with COVID-19. ⋯ Tocilizumab combined with or without favipiravir can effectively improve the pulmonary inflammation of COVID-19 patients and inhibit the deterioration of the disease.
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Biomed. Pharmacother. · Dec 2018
Randomized Controlled TrialEffect of intravenous magnesium sulfate on bupivacaine spinal anesthesia in preeclamptic patients.
Magnesium sulfate (MgSO4) is the standard therapy for the treatment of preeclampsia and prevention of eclamptic seizures in labor. This study aimed to determine the effect of the magnesium administered intravenously as a bolus prior to spinal anesthesia on the speed of onset and duration of the spinal anesthesia in preeclamptic women. ⋯ Intravenous MgSO4 can hasten the onset of sensory block, prolong the duration of sensory block, motor block and spinal anesthesia, alleviate postoperative pain, but not hasten the onset of motor block in preeclamptic women undergoing spinal anesthesia without additional side effects. (www.chictr.org.cn, registration number: ChiCTR-IOR-15006856).