Regulatory toxicology and pharmacology : RTP
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Regul. Toxicol. Pharmacol. · Jun 2013
Review Meta Analysis Comparative StudyThe effect on health of switching from cigarettes to snus - a review.
Interest in snus (Swedish type moist snuff) as an alternative to smoking is increasing, but the evidence on the health effects of switching from cigarettes to snus has not previously been reviewed. We identified six epidemiological cohort or case-control studies, all from Sweden, which allowed comparison of cancer or cardiovascular disease risk in current snus users who formerly smoked ("switchers") with that of never snus users who continued to smoke ("continuers") or of never snus users who quit smoking ("quitters"). ⋯ Based on estimates from four studies for ischaemic/coronary heart disease or acute myocardial infarction, meta-analyses gave combined relative risk estimates of 0.55 (95% confidence interval 0.45-0.68) for switchers vs. continuers and 1.02 (95% confidence interval 0.83-1.26) for switchers vs. quitters. Though based on limited evidence with some weaknesses, these results are consistent with a recent review which found no increased risk of cancer or heart disease from snus use.
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Regul. Toxicol. Pharmacol. · Jun 2013
Randomized Controlled Trial Comparative StudyChanges in levels of biomarkers of exposure observed in a controlled study of smokers switched from conventional to reduced toxicant prototype cigarettes.
Reduced toxicant prototype (RTP) cigarettes with substantially reduced levels of tobacco smoke toxicants have been developed. Evaluation of these prototype cigarettes included measurement of biomarkers of exposure (BoE) to toxicants in smokers switched from conventional cigarettes to the RTPs. A 6-week single-blinded randomised controlled study with occasional clinical confinement was conducted (