Statistics in medicine
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Statistics in medicine · Apr 2014
A marginal structural model for multiple-outcome survival data:assessing the impact of injection drug use on several causes of death in the Canadian Co-infection Cohort.
It is often the case that interest lies in the effect of an exposure on each of several distinct event types. For example, we are motivated to investigate in the impact of recent injection drug use on deaths due to each of cancer, end-stage liver disease, and overdose in the Canadian Co-infection Cohort (CCC). ⋯ An asymptotic variance estimator is derived, and a cumulative incidence function estimator is given. We compare the performance of the proposed marginal structural model for multiple-outcome data to that of conventional competing risks models in simulated data and demonstrate the use of the proposed approach in the CCC.