Journal of the American College of Cardiology
-
J. Am. Coll. Cardiol. · Sep 1992
Randomized Controlled Trial Clinical TrialAntiarrhythmic drug therapy and cardiac mortality in atrial fibrillation. The Stroke Prevention in Atrial Fibrillation Investigators.
The relation between cardiac mortality and antiarrhythmic drug administration has not been fully determined. This relation was analyzed in 1,330 patients enrolled in the Stroke Prevention in Atrial Fibrillation Study, a randomized clinical trial comparing warfarin, aspirin and placebo for the prevention of ischemic stroke or systemic embolism in patients with nonvalvular atrial fibrillation. ⋯ Although antiarrhythmic drug therapy was not randomly determined in this trial, the data suggest that in patients with atrial fibrillation and a history of congestive heart failure, the risk of such therapy may outweigh the potential benefit of maintaining sinus rhythm.
-
J. Am. Coll. Cardiol. · Sep 1992
Intraoperative evaluation of mitral valve regurgitation and repair by transesophageal echocardiography: incidence and significance of systolic anterior motion.
This study was designed to delineate the utility and results of intraoperative transesophageal echocardiography in the evaluation of patients undergoing mitral valve repair for mitral regurgitation. ⋯ Transesophageal echocardiography is a valuable adjunct in the intraoperative assessment of mitral valve repair.
-
J. Am. Coll. Cardiol. · Sep 1992
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialPAIMS 2: alteplase combined with heparin versus heparin in the treatment of acute pulmonary embolism. Plasminogen activator Italian multicenter study 2.
The effect of alteplase versus heparin in pulmonary embolism has not been studied extensively with serial pulmonary angiograms. ⋯ Alteplase resulted in a greater and faster improvement of the angiographic and hemodynamic variables compared with heparin. However, the high frequency of bleeding observed with alteplase in this trial suggests that patients should be carefully selected before thrombolytic therapy is given.