Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Jul 1993
Intravenous amiodarone for life-threatening tachyarrhythmias in children and young adults.
The purpose of this study was to evaluate the efficacy of intravenous amiodarone in young patients. ⋯ Intravenous amiodarone was well tolerated in this small series of patients. Postoperative ventricular tachycardia was responsive to intravenous amiodarone in 80% (8 of 10) of the patients (95% confidence interval 40% to 99%). Use of this drug in acute, postoperative tachyarrhythmias may be lifesaving in some patients when standard intravenous therapies fail.
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J. Am. Coll. Cardiol. · Jul 1993
Bolus intravenous nitroglycerin predominantly reduces afterload in patients with excessive arterial elastance.
We hypothesized that bolus intravenous nitroglycerin would be an afterload-reducing agent in patients with excessive initial afterload for their level of left ventricular systolic function. Conversely, bolus intravenous nitroglycerin should be a preload-reducing agent in patients without excessive initial afterload. ⋯ Patients with normal arterial elastance and ventricular function respond to nitroglycerin with a predominant preload reduction, whereas patients with either excessive arterial elastance or abnormal ventricular function respond with a predominant afterload reduction.