Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Oct 1995
Randomized Controlled Trial Comparative Study Clinical TrialDual-chamber pacing with a short atrioventricular delay in congestive heart failure: a randomized study.
This prospective study assessed the initial hemodynamic effects and long-term clinical benefits of dual-chamber pacing with a short atrioventricular (AV) delay in patients with chronic heart failure who had no traditional indication for pacemaker implantation. ⋯ Dual-chamber pacing with a short AV delay does not improve hemodynamic and clinical status or ejection fraction measured on the day after pacemaker implantation in patients with chronic congestive heart failure. Routine use of pacemaker therapy with a short AV delay aas a primary treatment of heart failure in patients without standard arrhythmic indications is unwarranted.
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J. Am. Coll. Cardiol. · Oct 1995
Randomized Controlled Trial Comparative Study Clinical TrialEfficacy and proarrhythmic hazards of pharmacologic cardioversion of atrial fibrillation: prospective comparison of sotalol versus quinidine.
This study compared the efficacy and safety of sotalol and quinidine for conversion and prevention of recurrent atrial fibrillation. ⋯ Quinidine is more effective than sotalol in terminating atrial fibrillation but is associated with more side effects. The proarrhythmic risk may be related to quinidine's propensity to increase disparity in ventricular repolarization. This risk warrants careful ECG monitoring during the 1st 4 to 7 days of therapy. Because most proarrhythmic effects occurred shortly after restoration of sinus rhythm, observation should continue > or = 2 to 3 days after sinus rhythm is reestablished.
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J. Am. Coll. Cardiol. · Oct 1995
Randomized Controlled Trial Comparative Study Clinical TrialCost-effectiveness of captopril therapy after myocardial infarction.
This study sought to assess the cost-effectiveness of captopril therapy for survivors of myocardial infarction. ⋯ We conclude that the cost-effectiveness of captopril therapy for 50- to 80-year old survivors of myocardial infarction with a low ejection fraction compares favorably with other interventions for survivors of myocardial infarction.
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J. Am. Coll. Cardiol. · Oct 1995
Comparative StudyIntraoperative validation of mitral inflow determination by transesophageal echocardiography: comparison of single-plane, biplane and thermodilution techniques.
This study investigated the accuracy of mitral inflow quantification using biplane transesophageal echocardiography. ⋯ This study validates the accuracy of measurements of mitral inflow using biplane transesophageal echocardiography with potential application for quantification of valvular regurgitation in the operating room. The results are further generalizable, indicating that orthogonal biplane measurements are both necessary and sufficient to ensure accuracy in area calculation for any elliptic structure.
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J. Am. Coll. Cardiol. · Oct 1995
Randomized Controlled Trial Multicenter Study Clinical TrialAngioplasty of complex lesions in ischemic rest angina: results of the Thrombolysis and Angioplasty in Unstable Angina (TAUSA) trial.
This study sought to analyze the role of complex lesion morphology on the acute results of angioplasty. ⋯ Complex lesions before coronary angioplasty increase acute complication rates after coronary angioplasty. Urokinase as administered in the TAUSA trial had significant adverse effects, especially in complex lesions. However, even in the placebo arm, complex lesions were associated with higher complication rates than simple lesions. Newer antithrombotic measures that particularly target the platelet may eventually decrease complication rates in these lesions.