Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Nov 2004
Comparative StudyLeft ventricular dyssynchrony predicts response and prognosis after cardiac resynchronization therapy.
This study was designed to predict the response and prognosis after cardiac resynchronization therapy (CRT) in patients with end-stage heart failure (HF). ⋯ Patients with LV dyssynchrony >/=65 ms respond to CRT and have an excellent prognosis after CRT.
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J. Am. Coll. Cardiol. · Nov 2004
Comparative StudyMyosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy.
We sought to determine the frequency and phenotype of mutations in myosin binding protein C (MYBPC3) in a large outpatient cohort of patients with hypertrophic cardiomyopathy (HCM) seen at our tertiary referral center. ⋯ This study defines the frequency and associated phenotype for MYBPC3 and/or multiple mutations in HCM in the largest cohort to date. In this cohort, unrelated patients with MYBPC3-HCM virtually mimicked the phenotype of those with mutations in the beta-myosin heavy chain. Patients with multiple mutations had the most severe phenotype.