Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Aug 2005
Effects of long-term bosentan in children with pulmonary arterial hypertension.
This study investigated the long-term outcome of children with pulmonary arterial hypertension (PAH) treated with bosentan therapy, with or without concomitant prostanoid therapy. ⋯ These data suggest that bosentan, an oral endothelin ET(A)/ET(B) receptor antagonist, with or without concomitant prostanoid therapy, is safe and efficacious for the treatment of PAH in children.
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J. Am. Coll. Cardiol. · Aug 2005
Letter Randomized Controlled Trial Clinical TrialA randomized trial comparing 1 mg of oral vitamin K with no treatment in the management of warfarin-associated coagulopathy in patients with mechanical heart valves.
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J. Am. Coll. Cardiol. · Aug 2005
Comparative StudyRemote ischemic preconditioning provides early and late protection against endothelial ischemia-reperfusion injury in humans: role of the autonomic nervous system.
The aim of this study was to characterize the time course and neuronal mechanism of remote ischemic preconditioning (RIPC) of the vasculature in humans. ⋯ Remote ischemic preconditioning in humans has two phases of protection against endothelial IR injury; an early (short) and late (prolonged) phase, both of which are neuronally mediated. The potential for late phase RIPC to provide prolonged protection during clinical IR syndromes merits investigation.
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J. Am. Coll. Cardiol. · Aug 2005
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialHigh-volume hemofiltration after out-of-hospital cardiac arrest: a randomized study.
The study examined the effect of isovolumic high-volume hemofiltration (HF) alone or combined with mild hypothermia (HT) on survival after out-of-hospital cardiac arrest (OHCA) with initial ventricular fibrillation or asystole. ⋯ The HF may improve the overall prognosis after resuscitation from OHCA. Combination of HF with mild HT is feasible and should be evaluated in larger trials.