Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Feb 2009
Randomized Controlled Trial Multicenter StudyEffect of intravenous FX06 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction results of the F.I.R.E. (Efficacy of FX06 in the Prevention of Myocardial Reperfusion Injury) trial.
The purpose of this study was to investigate whether FX06 would limit infarct size when given as an adjunct to percutaneous coronary intervention. ⋯ In this proof-of-concept trial, FX06 reduced the necrotic core zone as one measure of infarct size on magnetic resonance imaging, while total late enhancement was not significantly different between groups. The drug appears safe and well tolerated. (Efficacy of FX06 in the Prevention of Myocardial Reperfusion Injury [F.I.R.E.]; NCT00326976).
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J. Am. Coll. Cardiol. · Feb 2009
Importance of venous congestion for worsening of renal function in advanced decompensated heart failure.
To determine whether venous congestion, rather than impairment of cardiac output, is primarily associated with the development of worsening renal function (WRF) in patients with advanced decompensated heart failure (ADHF). ⋯ Venous congestion is the most important hemodynamic factor driving WRF in decompensated patients with advanced heart failure.
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J. Am. Coll. Cardiol. · Feb 2009
Clinical TrialCharacteristics of recurrent ventricular fibrillation associated with inferolateral early repolarization role of drug therapy.
Our purpose was to evaluate the efficacy of antiarrhythmic drugs (AADs) in recurrent ventricular fibrillation (VF) associated with inferolateral early repolarization pattern on the electrocardiogram. ⋯ Multiple recurrences of VF occurred in 27% of patients with early repolarization abnormality and may be life threatening. Isoproterenol in acute cases and quinidine in chronic cases are effective AADs.
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J. Am. Coll. Cardiol. · Feb 2009
Survival and neurologic recovery in patients with ST-segment elevation myocardial infarction resuscitated from cardiac arrest.
We examined outcomes of patients resuscitated from cardiac arrest owing to ST-segment elevation myocardial infarction (STEMI) and predictors of survival and neurologic recovery. ⋯ When resuscitated patients with STEMI are being evaluated in the emergency department, serious consideration should be given to emergent angiography and revascularization, regardless of neurologic status.