Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Aug 2010
Transapical aortic valve implantation in 175 consecutive patients: excellent outcome in very high-risk patients.
The aim of this study was to evaluate the outcome of transapical aortic valve implantation in a single center with expanded procedural experience and to compare it with predicted risk for conventional aortic valve surgery. ⋯ The outcome of transapical aortic valve implantation was very favorable and already reproducible during the learning curve. The method has become de facto our institutional primary choice for treatment of high-risk patients with severe aortic valve stenosis.
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J. Am. Coll. Cardiol. · Aug 2010
Survival in schistosomiasis-associated pulmonary arterial hypertension.
The objective of this study was to evaluate the natural history of untreated schistosomiasis-associated pulmonary arterial hypertension (Sch-PAH) patients as compared to idiopathic pulmonary arterial hypertension (IPAH) with respect to hemodynamics recorded at presentation and 36 months survival. ⋯ Sch-PAH has a more benign clinical course than IPAH despite a lack of demonstrable acute vasoreactivity at hemodynamic evaluation.
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J. Am. Coll. Cardiol. · Aug 2010
Earlier intervention in the management of hypercholesterolemia: what are we waiting for?
The thesis advanced here is that we are initiating treatment of hypercholesterolemia (and other risk factors) too late in life. Initiating treatment at, for example, age 30 years instead of age 60 years might very well prevent not just 30% of events, as in the 5-year statin trials, but perhaps as many as 60%.