Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Aug 2019
Multicenter Study Observational StudyThromboembolic Risk After Atriopulmonary, Lateral Tunnel, and Extracardiac Conduit Fontan Surgery.
Thromboembolic events contribute greatly to morbidity and mortality following Fontan surgery for univentricular hearts. ⋯ The EC Fontan was independently associated with a lower thromboembolic risk after controlling for time-varying effects of atrial arrhythmias and thromboprophylaxis.
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J. Am. Coll. Cardiol. · Aug 2019
Multicenter StudyPredicting Major Adverse Events in Patients With Acute Myocardial Infarction.
Early and accurate detection of short-term major adverse cardiac events (MACE) in patients with suspected acute myocardial infarction (AMI) is an unmet clinical need. ⋯ The ESC hs-cTn 0/1 h algorithm better balanced efficacy and safety in the prediction of MACE, whereas the extended algorithm is the preferred option for the rule-out of 30-day MACE + UA. (Advantageous Predictors of Acute Coronary Syndromes Evaluation [APACE]; NCT00470587).
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J. Am. Coll. Cardiol. · Aug 2019
Multicenter StudyDigoxin Discontinuation and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction.
The deleterious effects of discontinuation of digoxin on outcomes in ambulatory patients with chronic heart failure (HF) with reduced ejection fraction (HFrEF) receiving angiotensin-converting enzyme inhibitors are well-documented. ⋯ Among hospitalized older patients with HFrEF on more contemporary guideline-directed medical therapies, discontinuation of pre-admission digoxin therapy was associated with poor outcomes.