Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Oct 2020
Multicenter StudyPrognostic Utility of Right Ventricular Remodeling Over Conventional Risk Stratification in Patients With COVID-19.
Coronavirus disease 2019 (COVID-19) is a growing pandemic that confers augmented risk for right ventricular (RV) dysfunction and dilation; the prognostic utility of adverse RV remodeling in COVID-19 patients is uncertain. ⋯ Adverse RV remodeling predicts mortality in COVID-19 independent of standard clinical and biomarker-based assessment.
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J. Am. Coll. Cardiol. · Oct 2020
Comparative StudyClinical and Angiographic Features of Patients With Out-of-Hospital Cardiac Arrest and Acute Myocardial Infarction.
Sudden cardiac arrest is a serious complication of acute myocardial infarction (MI). Although in-hospital mortality from MI has decreased, the mortality of MI patients complicated with out-of-hospital cardiac arrest (OHCA) remains high. However, the features of acute MI patients with OHCA have not been well known. ⋯ Younger age, no use of calcium-channel antagonists, worse renal function, larger infarct size, culprit lesion in the left main coronary artery, and having chronic total occlusion were associated with OHCA.
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J. Am. Coll. Cardiol. · Oct 2020
Multicenter StudyIncidence, Characteristics, Predictors, and Outcomes of Surgical Explantation After Transcatheter Aortic Valve Replacement.
Currently, there is a paucity of information on surgical explantation after transcatheter aortic valve replacement (TAVR). ⋯ The present study provides updated evidence on the incidence, timing, and outcomes of surgical explantation of a TAVR prosthesis. Although the overall incidence was low, short-term mortality was high. These findings stress the importance of future mechanistic studies on TAVR explantation and may have implications on lifetime management of aortic stenosis, particularly in younger patients.
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J. Am. Coll. Cardiol. · Oct 2020
Anticoagulation, Bleeding, Mortality, and Pathology in Hospitalized Patients With COVID-19.
Thromboembolic disease is common in coronavirus disease-2019 (COVID-19). There is limited evidence on the association of in-hospital anticoagulation (AC) with outcomes and postmortem findings. ⋯ AC was associated with lower mortality and intubation among hospitalized COVID-19 patients. Compared with prophylactic AC, therapeutic AC was associated with lower mortality, although not statistically significant. Autopsies revealed frequent thromboembolic disease. These data may inform trials to determine optimal AC regimens.