Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Oct 2021
Three- Versus Two-Drug Therapy for Patients With Newly Diagnosed Pulmonary Arterial Hypertension.
In pulmonary arterial hypertension (PAH), there are no data comparing initial triple oral therapy with initial double oral therapy. ⋯ In patients with newly diagnosed PAH, both treatment strategies markedly reduced PVR by week 26, with no significant difference between groups (primary endpoint not met). Exploratory analyses suggested a possible signal for improved long-term outcomes with initial triple versus initial double oral therapy.