Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Jul 2006
Comment Randomized Controlled Trial Multicenter StudyPost-reperfusion myocardial infarction: long-term survival improvement using adenosine regulation with acadesine.
The purpose of this study was to assess the safety and efficacy of the adenosine regulating agent (ARA) acadesine for reducing long-term mortality among patients with post-reperfusion myocardial infarction (MI). ⋯ Acadesine is the first therapy proven to be effective for reducing the severity of acute post-reperfusion MI, substantially reducing the risk of dying over the 2 years after infarction.
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J. Am. Coll. Cardiol. · May 2006
Randomized Controlled Trial Multicenter StudyTreatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan.
We sought to determine the optimal dose of the selective endothelin A (ET(A)) receptor antagonist sitaxsentan for the treatment of pulmonary arterial hypertension (PAH); for observation only, an open-label (OL) bosentan arm was included. ⋯ Treatment with the selective ET(A) receptor antagonist sitaxsentan, orally once daily at a dose of 100 mg, improves exercise capacity and WHO FC in PAH patients, with a low incidence of hepatic toxicity.
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J. Am. Coll. Cardiol. · May 2006
Multicenter Study Clinical TrialEffects of time, dose, and inversion time for acute myocardial infarct size measurements based on magnetic resonance imaging-delayed contrast enhancement.
This study sought to investigate the influence of time, dose, and inversion time (TI) and their interactions on myocardial infarct size measurements to establish the foundation for a standardized protocol for multicenter trials. ⋯ The AMI size can be measured with MRI using a contrast dose between 0.1 and 0.2 mmol/kg and a time window of 5 to 30 min after contrast administration, provided that the TI is adjusted.
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J. Am. Coll. Cardiol. · Feb 2006
Multicenter StudyHealth status identifies heart failure outpatients at risk for hospitalization or death.
We tested the hypothesis that one health status measure, the Kansas City Cardiomyopathy Questionnaire (KCCQ), provides prognostic information independent of other clinical data in outpatients with heart failure (HF). ⋯ A low KCCQ score is an independent predictor of poor prognosis in outpatients with HF.
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J. Am. Coll. Cardiol. · Aug 2005
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialHigh-volume hemofiltration after out-of-hospital cardiac arrest: a randomized study.
The study examined the effect of isovolumic high-volume hemofiltration (HF) alone or combined with mild hypothermia (HT) on survival after out-of-hospital cardiac arrest (OHCA) with initial ventricular fibrillation or asystole. ⋯ The HF may improve the overall prognosis after resuscitation from OHCA. Combination of HF with mild HT is feasible and should be evaluated in larger trials.