Hepatology : official journal of the American Association for the Study of Liver Diseases
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Hepatorenal failure, a well-recognized complication of established liver disease, is characterized by early renal hemodynamic changes (vasoconstriction) before clinically recognized kidney disease. This renal vasoconstriction (increased renal vascular resistance) should be detectable noninvasively by Doppler ultrasonography. We studied whether renal Doppler ultrasonography detects abnormalities in patients with nonazotemic liver disease and its prognostic value for subsequent kidney status. ⋯ Hepatorenal syndrome developed in 26% (20/76) of subjects with an elevated resistive index and 1% (1/104) of those with a normal resistive index (p < 0.00005). Cox regression analysis identified resistive index as a significant independent predictor of subsequent hepatorenal syndrome (p < 0.00005) and kidney dysfunction (p < 0.00005). Renal duplex Doppler ultrasonography can noninvasively identify a subgroup of nonazotemic patients with liver disease that is at significantly higher risk for subsequent development of kidney dysfunction and the hepatorenal syndrome.