The Science of the total environment
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In this study, the following in vitro and in vivo experiments were carried out: (a) Rats were exposed to the radionuclide 57Co2+ ions in single intraperitoneal or intravenous doses (from 10 ng to 1 mg Co/rat) or to 50 ng Co/rat/day through drinking water for 109 days. The target tissue for cobalt depended on the dosage and route of administration (e.g. lung, kidney or bone). Excretion took place mainly through urine (i.p. and i.v. administration) or feces. ⋯ At 10 microM, cell growth was reduced to about 30%. No inhibition was found at 1 microM. Morphological transformation assays gave negative results when the cells were exposed to 1000 microM of cobalt.