Journal of hypertension
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Journal of hypertension · Nov 1994
Comparative Study Clinical Trial Controlled Clinical TrialEndogenous opioid system and atrial natriuretic factor in normotensive offspring of hypertensive parents at rest and during exercise test.
To investigate the effects of the endogenous opioid system on plasma atrial natriuretic factor (ANF) levels during sympathetic hyperactivity. ⋯ Our findings show that plasma met-enkephalin, dynorphin B, ANF and noradrenaline levels at rest and during exercise are higher in normotensive offspring than in controls. The effects of naloxone indicate that in normotensive offspring at rest the opioid system does not affect ANF release, whereas during exercise it attenuates ANF hypersecretion, possibly by reducing noradrenaline release.