Journal of hypertension
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Journal of hypertension · Aug 2004
Altered profile of baroreflex and autonomic responses to lower body negative pressure in chronic orthostatic intolerance.
Chronic orthostatic intolerance (COI) is a common and disabling autonomic syndrome of unclear pathophysiology. We tested the hypothesis that baroreflex and autonomic responses to graded lower body suction (LBNP, up to -40 mmHg) could be altered in COI patients. ⋯ Patients with chronic orthostatic intolerance show distinct signs of altered baroreflex and autonomic regulation of the SA node and of the vasculature in response to graded LBNP.