Journal of hypertension
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Journal of hypertension · Jul 2007
Multicenter StudyCYBA C242T gene polymorphism and flow-mediated vasodilation in a population of young adults: the Cardiovascular Risk in Young Finns Study.
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is a major source of the superoxide anion that contributes to decreased nitric oxide bioavailability in the vasculature. The C242T polymorphism of the CYBA gene that encodes p22phox, a component of NADPH oxidase, has been found to modulate superoxide production. We examined the relationship of the C242T polymorphism with endothelial-dependent brachial artery flow-mediated vasodilatation (FMD) in a population-based sample of young healthy adults. ⋯ The C242T polymorphism of the CYBA gene seems to be related to endothelial function in a population-based sample of young healthy adults. Overweight and smoking status may modify this genetic effect.
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Journal of hypertension · Jul 2007
Arterial stiffness, cardiovagal baroreflex sensitivity and postural blood pressure changes in older adults: the Rotterdam Study.
Arterial stiffness may be involved in the impairment of the arterial baroreflex. In the present study the associations between arterial stiffness and cardiovagal baroreflex sensitivity (BRS) and between BRS and postural blood pressure (BP) changes were investigated within the framework of the Rotterdam Study. ⋯ In a large population of older subjects, arterial stiffness appears to be an independent determinant of impaired BRS. Within the same population, impaired BRS was associated with orthostatic BP changes.
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Journal of hypertension · Jul 2007
Biography Historical ArticleKarl Samuel Ritter Von Basch: the sphygmomanometer and the Empire.
The measurement of blood pressure is essential in clinical practice, and sphygmomanometers are a necessary appliance in every medical office. One of the most important men in the development of the sphygmomanometer was the Austrian physician Karl Samuel Ritter Von Basch. ⋯ He also had an important role in history by witnessing, and documenting, the short lived Second Mexican Empire of Maximilian of Hapsburg. His contributions to Mexico's history and to the study of hypertension make him a notable figure, and one that should be remembered.