Journal of hypertension
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Journal of hypertension · Jun 2012
Randomized Controlled TrialPredictors of lowering SBP to assigned targets at 12 months in the Secondary Prevention of Small Subcortical Strokes study.
Lowering blood pressure for secondary stroke prevention remains a challenge. These analyses were conducted to identify factors predicting achievement of SBP targets in the Secondary Prevention of Small Subcortical Strokes (SPS3) study. ⋯ These results demonstrate that it is feasible to achieve targets of SBP control in this multiethnic stroke cohort across multiple sites and countries. The results highlight the important variables reflecting clinical site management.
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Journal of hypertension · Jun 2012
Liver growth factor treatment reverses vascular and plasmatic oxidative stress in spontaneously hypertensive rats.
Liver growth factor (LGF) is an albumin-bilirubin complex with antioxidant actions in vitro. In spontaneously hypertensive rats (SHRs), short LGF treatment exerts antihypertensive and antifibrotic effects. ⋯ LGF treatment of SHRs normalizes the level of plasma oxidative stress biomarkers through a reduction of vascular superoxide anion produced by NADPH and xanthine oxidases. These effects might be linked to the cardiovascular regenerative actions of LGF.