Cancer investigation
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Cancer investigation · Jun 2009
ReviewHeparins attenuate cancer metastasis: are selectins the link?
Heparin is often used to prevent or treat thromboembolism in cancer patients. Clinical and experimental evidence suggest that heparin also has anticancer activities. ⋯ Heparin inhibits selectin-mediated interactions of tumor cells with leukocytes, platelets, and endothelial cells, which are likely to mediate the initial steps of hematogenous metastasis. Prospective clinical trials can be designed on the basis of the insights obtained from experimental studies.