Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
-
Randomized Controlled Trial
Oral paracetamol premedication effect on maternal pain in amniocentesis: a randomised double blind placebo-controlled trial.
The objective of this study was to evaluate the effectiveness of oral paracetamol premedication in decreasing the maternal pain during amniocentesis. A randomised double blind placebo-controlled trial was conducted. Two hundred and forty participants were equally allocated into two groups (one paracetamol and one placebo). ⋯ What the results of this study add? Paracetamol is effective in decreasing the maternal pain during and after amniocentesis. What the implications are of these findings for clinical practice and/or further research? Pregnant women who need amniocentesis should be counselled that paracetamol could be administered for relieving the pain that may occur from the procedure. However, further study should be conducted to find the optimal dosage of paracetamol for relieving the pain in amniocentesis along with a large RCT with a long-term follow-up to evaluate the side effects of paracetamol.