Journal of neuro-oncology
-
Journal of neuro-oncology · Aug 2005
Case ReportsSylvian meningioma without dural attachment in an adult.
This paper presents a rare case of a sylvian meningioma in a 35-year-old male. The patient visited our hospital because of a 10-year history of simple partial seizures. Magnetic resonance imaging revealed a 3.5-cm, well-circumscribed, homogenously enhanced, circular mass without dural attachments in the left insular region. ⋯ The tumor was excised, and a histological diagnosis of a transitional meningioma without a malignancy was made. A Sylvian meningioma without dural attachment is quite rare, and a preoperative differentiation of this lesion is generally difficult. This paper discusses the characteristics and possible pathogenesis of meningiomas without a dural detachment.
-
Journal of neuro-oncology · Aug 2005
Comparative StudyMagnetic resonance imaging and biological markers in pituitary adenomas with invasion of the cavernous sinus space.
The preoperative diagnosis of cavernous sinus invasion remains difficult and controversial, and there are currently no reliable histological or molecular markers that predict pituitary tumour behaviour and response to treatment. We evaluated 45 patients with pituitary adenoma. The results have shown that the sensitivity of MRI for indicating cavernous sinus invasion in this prospective study was 60%, specificity 85%, positive predictive value 83.33%, negative predictive value 62.96%. ⋯ In conclusion, parasellar extension of pituitary adenomas through the medial wall of the cavernous sinus diagnosed at surgery, can be determined by radiology with sensitive gadolinium-enhanced MRI. Although our study has shown that MVD and the expression of VEGF, Ki-67, nm23 and MMP-9 have associations with invasiveness of pituitary adenomas, they are lack of specificity. These markers can only provide some useful informations on the therapeutic strategy of pituitary adenomas.