Journal of neuro-oncology
-
Journal of neuro-oncology · Mar 2007
Acute morphological sequelae of photodynamic therapy with 5-aminolevulinic acid in the C6 spheroid model.
Aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) may represent a treatment option for malignant brain tumors. We used a three-dimensional cell culture system, the C6 glioma spheroid model, to study acute effects of PDT and how they might be influenced by treatment conditions. ⋯ PDT of experimental glioma results in rapid and significant cell death that could be verified as acute necrosis immediately after irradiation. This effect depended on O(2) concentration and spheroid size.