Journal of pharmaceutical and biomedical analysis
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J Pharm Biomed Anal · Aug 2018
Synthetic cannabinoid BB-22 (QUCHIC): Human hepatocytes metabolism with liquid chromatography-high resolution mass spectrometry detection.
Clandestine laboratories continue producing new synthetic cannabinoids that mimic and magnify natural cannabinoids effects to circumvent drug scheduling legislation. New synthetic cannabinoids are highly potent and responsible for many acute intoxications and deaths. Characterization of metabolic pathways is critical to identify metabolite markers whose detection can prove intake. ⋯ Hydrolysis of biological samples before analysis is strongly suggested to improve detection of phase I metabolites. BB-22 3-carboxyindole is not specific for BB-22 intake, as it was previously detected as a minor MDMB-CHMICA and ADB-CHMICA metabolite. Consumption of these two synthetic cannabinoids should be ruled out to confirm BB-22 intake.