The American journal of emergency medicine
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Randomized Controlled Trial Comparative Study
A randomized, placebo-controlled trial of ondansetron, metoclopramide, and promethazine in adults.
The objective of the study was to assess whether ondansetron has superior nausea reduction compared with metoclopramide, promethazine, or saline placebo in emergency department (ED) adults. ⋯ Our study shows no evidence that ondansetron is superior to metoclopramide and promethazine in reducing nausea in ED adults. Early study termination may have limited detection of ondansetron's superior nausea reduction over saline.