Resuscitation
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In our previous report, the effect of CCPR (an intracarotid hypothermic infusion combined with the existing CPR) has been described by the authors on dogs in which cardiac arrest had been induced by the inhalation of nitrous oxide. This report contains a new continuous brain cooling method, using a Resusci Pump TM-1 which has been newly devised by us and which has a carotid-carotid bypass in order to reduce oxygen consumption and cerebral metabolism while maintaining a continuous cerebral blood flow. Cardiac arrest was induced experimentally by electrical stimulation. ⋯ This resulted in the minimum effect on circulatory and respiratory system as compared to the effects caused by general hypothermia. Furthermore, the continuous brain cooling decreased cerebral metabolism and CMRO2, and prevented a progressive development of cerebral hypoxia Cerebral perfusion at a given constant pressure may protect the brain tissue from the disturbance of cerebral microcirculation. Therefore, we might expect the continuous brain cooling to have a beneficial effect on cerebral respiration, circulation and metabolism.
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Laser doppler flowmetry (LDF) is a new non-invasive technique by which microcirculation changes in tissue can be studied. In recent papers, this technique has been used to measure microflow in standardized fluid models, in animals and in human clinical situations. LDF utilizes the doppler shift, i.e. the frequency (wave length) change that light as well as all waves undergo being reflected by moving objects such as, e.g. red blood cells. ⋯ Patient in shock. LDF seems to be an interesting new non-invasive technique, supplying a good definition of the skin microflow. In the future, this technique could be one of the non-invasive techniques used for intensive care, defining the microcirculation state of a patient.