Resuscitation
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Multicenter Study
Duration of hospital participation in Get With the Guidelines-Resuscitation and survival of in-hospital cardiac arrest.
Get With the Guidelines (GWTG-R) is a data registry and quality improvement program for in-hospital cardiac arrest (IHCA). It is unknown if duration of hospital participation in GWTG-R is associated with IHCA outcomes. ⋯ Duration of hospital participation in GWTG-R was significantly associated with survival of the IHCA event, but not with survival to discharge. In VT/VF arrests, this association may have been mediated by improvements in time to defibrillation.
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Infusion of bone marrow mesenchymal stem cells (MSCs) improves myocardial function following myocardial infarction (MI). The mechanisms, however, remain controversial. This study was to investigate changes of MSCs in vivo after administration into myocardial infarcted rats. Our hypothesis was that MSCs might differentiate into contractile myocytes and improve myocardial function in vivo. ⋯ MSCs can differentiate into beating cardiomyocytes in a rat model of MI and improve myocardial function.
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Randomized Controlled Trial
The "Resus:Station": the use of clinical simulations in a randomised crossover study to evaluate a novel resuscitation trolley.
Inadequately designed equipment has been implicated in poor efficiency and critical incidents associated with resuscitation. A novel resuscitation trolley (Resus:Station) was designed and evaluated for impact on team efficiency, user opinion, and teamwork, compared with the standard trolley, in simulated cardiac arrest scenarios. ⋯ We conclude that in this simulated environment, the new design of trolley is safe to use, and has the potential to improve efficiency at a resuscitation attempt.
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Cardiopulmonary resuscitation (CPR) using extracorporeal life support (ECLS) system has been successfully used to support patients with in- and out-of-hospital cardiac arrest (IHCA, OHCA) when conventional measures have failed. The purpose of the current study is to report on our experience with extracorporeal CPR in non-postcardiotomy patients. ⋯ CPR using modern miniaturized ECLS systems should be established in the treatment of prolonged cardiac arrest and unsuccessful conventional CPR in selected patients. CPR with ECLS for OHCA has worse outcomes compared to IHCA. Duration of CPR was independent risk factor for mortality after extracorporeal CPR.
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BACKGROUND AND GOAL OF STUDY: The relationship between chest compression rate and compression depth is unknown. In order to characterise this relationship, we performed an observational study in prehospital cardiac arrest patients. We hypothesised that faster compressions are associated with decreased depth. ⋯ This study showed an association between higher compression rates and lower compression depths. Avoiding excessive compression rates may lead to more compressions of sufficient depth.