The British journal of oral & maxillofacial surgery
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Br J Oral Maxillofac Surg · Apr 1986
Randomized Controlled Trial Comparative Study Clinical TrialA double-blind placebo-controlled comparison of three ibuprofen/codeine combinations and aspirin.
In a double-blind, single dose study of analgesic efficacy, 165 patients who were expected to develop moderate to severe pain following the removal of an impacted mandibular third molar tooth were allocated to receive aspirin, placebo, or an increasing dose of a fixed ratio ibuprofen/codeine combination. The degree of pain experienced prior to medication was noted and the patients were asked to record the degree of pain and of pain relief hourly for the following 5 hours. ⋯ There were few side effects and only one severe reaction was reported by a patient in the high dose group. To avoid side effects it is suggested that the medium-dose combination, ibuprofen 400 mg/codeine 30 mg, is optimal.