International journal of psychophysiology : official journal of the International Organization of Psychophysiology
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Int J Psychophysiol · Jan 2018
Altered resting-state functional connectivity in patients with obsessive-compulsive disorder: A magnetoencephalography study.
Aberrant cortical-striatal-thalamic-cortical circuits have been implicated in the pathophysiology of obsessive-compulsive disorder (OCD). However, the neurobiological basis of OCD remains unclear. We compared patterns of functional connectivity in patients with OCD and in healthy controls using resting-state magnetoencephalography (MEG). ⋯ The OCD group exhibited significantly lower phase synchronization among the insula, orbitofrontal cortex, and cortical regions of the limbic lobe in all band frequencies, except in the delta band. Altered functional networks in the resting state may be associated with the pathophysiology of OCD. These MEG findings indicate that OCD is associated with decreased functional connectivity in terms of phase synchrony, particularly in the insula, orbitofrontal cortex, and cortical regions of the limbic lobe.
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Int J Psychophysiol · Jan 2018
Reliability of measurements for sub-painful and painful perception on artificial electrical stimulations.
Artificial electrical stimulation is a common type of stimulus to induce sub-painful and painful sensation in clinical or neuroscience experiments. The Numerical Rating Scale (NRS) is often used to evaluate subjective perception due to external stimulations. Yet the relationship between the intensity levels of electrical stimulations and self-perception has seldom been examined. ⋯ The ICCs were the highest for the weakest sub-nociceptive and nociceptive stimuli. For the stimulus recognition task, accuracy was also found to be highest for the weakest sub-nociceptive stimulus (κ=0.67) and lowest for the strongest nociceptive stimulus (κ=0.34). The results suggest that, with adequate training, NRS can be a reliable measurement tool for both sub-painful and painful rating due to electrical stimulation.