Pharmaceutical research
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Pharmaceutical research · Jan 1996
Pharmacokinetic-pharmacodynamic modeling of the antibiotic effect of piperacillin in vitro.
It was the aim of the present study to investigate the in vitro antimicrobial effects of the beta-lactam antibiotic piperacillin on Escherichia coli using concentration-time profiles similar to those encountered in vivo. ⋯ Based on the in vitro data a more frequent administration of piperacillin will be more efficacious. The proposed PK-PD-model allows a more detailed evaluation of dosing regimens than the use of minimum inhibitory concentrations.