Pharmaceutical research
-
Pharmaceutical research · Jul 1996
In vitro and in vivo evaluation in rabbits of a controlled release 5-fluorouracil subconjunctival implant based on poly(D,L-lactide-co-glycolide).
To design a controlled release 5-fluorouracil (5-FU) implant to provide prolonged antifibroblast concentrations of 5-FU in the subconjunctival tissues but low concentrations of 5-FU in other ocular tissues. ⋯ The CM1 implant maintained steady antifibroblast levels in target tissues and minimized levels in nontarget tissues.