Pharmaceutical research
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Pharmaceutical research · Mar 1998
Comparative StudyControlled release gel of ibuprofen and lidocaine in epidural use--analgesia and systemic absorption in pigs.
Reduction of the frequency of injections and localization of the absorption of drug molecules to the injection site would be of great advantage in epidural pain treatment. The epidural use of a controlled release gel of lidocaine and ibuprofen was studied. ⋯ These results demonstrate poloxamer gel to be a promising controlled-release, injectable epidural formulation for the management of pain.
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Pharmaceutical research · Mar 1998
Comparative StudyInfluence of different fat emulsion-based intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol.
The influence of different intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol was investigated using the effect on the EEG (11.5-30 Hz) as pharmacodynamic endpoint. ⋯ The pharmacokinetics and pharmacodynamics of propofol are not affected by to a large extent the type of emulsion nor by the concentration of propofol in the intravenous formulation.