Pharmaceutical research
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Pharmaceutical research · Aug 2007
In vivo effects of glycyl-glutamate and glycyl-sarcosine on gabapentin oral absorption in rat.
The objective of this study was to evaluate the in vivo consequences of glycyl-glutamate coadministration on gabapentin oral absorption. ⋯ These findings are unique in demonstrating that under physiologic, in vivo conditions, the luminal presence of glycyl-glutamate could dramatically enhance the Cmax and AUC(0-6 h) of gabapentin. The results are consistent with previous in situ intestinal perfusion studies in rat, and establish a functional interaction between the activities of PEPT1 and amino acid exchangers.