Pharmaceutical research
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Pharmaceutical research · Jul 2009
Encouraging the move towards predictive population models for the obese using propofol as a motivating example.
To develop a predictive pharmacokinetic model for propofol that could inform development of a dosing strategy for the obese population. ⋯ LBW as a covariate provides a plausible mechanistic explanation for an observed nonlinear increase in drug CL with TBW and may be suitable for developing dosing strategies that are appropriate for use in the obese population.