Pharmaceutical research
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Pharmaceutical research · Nov 2011
Mitochondrial antioxidants alleviate oxidative and nitrosative stress in a cellular model of sepsis.
Mitochondrial dysfunction plays a key role in sepsis. ⋯ Mitochondria are heavily implicated in sepsis. Mitochondrial antioxidants provide a mechanistic model for the development of potential therapies.
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Pharmaceutical research · Nov 2011
Improvement of cerebral metabolism mediated by Ro5-4864 is associated with relief of intracranial pressure and mitochondrial protective effect in experimental brain injury.
To investigate the possible impact of reduction of mitochondrial membrane permeabilization by modulation of the 18 kDa translocator protein mediated by Ro5-4864 over post-traumatic cerebral edema and metabolic crisis. ⋯ The present study shows that Ro5-4864 has a favorable effect on the fate of injured brain, presumably mediated by improvement of metabolism. It further suggests that improvement of metabolism may contribute to ICP relief.