Pharmaceutical research
-
Pharmaceutical research · May 2012
Force dependent internalization of magnetic nanoparticles results in highly loaded endothelial cells for use as potential therapy delivery vectors.
To investigate the kinetics, mechanism and extent of MNP loading into endothelial cells and the effect of this loading on cell function. ⋯ Our results suggest that endothelial cell uptake of MNPs is a force dependent process. The in vitro assays determined that cell health is not adversely affected by high MNP loadings, allowing these highly magnetically responsive cells to be potentially beneficial therapy (gene, drug or cell) delivery systems.