Pharmaceutical research
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Pharmaceutical research · Jun 2012
Comparative StudyA bodyweight-dependent allometric exponent for scaling clearance across the human life-span.
To explore different allometric equations for scaling clearance across the human life-span using propofol as a model drug. ⋯ A model was developed for scaling clearance over the entire human life-span with a single continuous equation, in which the exponent of the bodyweight-based exponential equation varied with bodyweight.