Pharmaceutical research
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Pharmaceutical research · Jan 2014
Randomized Controlled Trial Clinical TrialClinical potential of a silk sericin-releasing bioactive wound dressing for the treatment of split-thickness skin graft donor sites.
An ethyl alcohol-precipitated silk sericin/PVA scaffold that controlled the release of silk sericin was previously developed and applied for the treatment of full-thickness wounds in rats and demonstrated efficient healing. In this study, we aimed to further evaluate the clinical potential of this scaffold, hereafter called "silk sericin-releasing wound dressing", for the treatment of split-thickness skin graft donor sites by comparison with the clinically available wound dressing known as "Bactigras®". ⋯ We introduce this novel silk sericin-releasing wound dressing as an alternative treatment for split-thickness skin graft donor sites.