Pharmaceutical research
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Pharmaceutical research · Apr 2016
Translational Modeling in Schizophrenia: Predicting Human Dopamine D2 Receptor Occupancy.
To assess the ability of a previously developed hybrid physiology-based pharmacokinetic-pharmacodynamic (PBPKPD) model in rats to predict the dopamine D2 receptor occupancy (D2RO) in human striatum following administration of antipsychotic drugs. ⋯ The rat hybrid PBPKPD model structure, integrated with in vitro information and human pharmacokinetic and physiological information, constitutes a scientific basis to predict the time course of D2RO in man.