Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
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This retrospective review of 85 patients presents the prognostic factors and disease outcome for localized synovial sarcoma treated with conservation surgery and radiotherapy. Tumors were located in the lower extremity (48), upper extremity (20), trunk (11), and head and neck (6). All patients were treated with limited excision and radiotherapy. ⋯ Ten-year metastatic rates according to tumor size, s, were s < or = 2 cm, 0%; 2 < s < or = 5 cm, 35%; 5 < s < or = 10 cm, 59%; 10 cm < s, 100%. Our retrospective data failed to reveal benefits for adjuvant chemotherapy either in univariate or multivariate analysis. Eight patients (9%) had local recurrence as the initial failure and 4 others had local failure after disease appeared elsewhere, yielding a 5-year actuarial local recurrence rate of 14%.(ABSTRACT TRUNCATED AT 250 WORDS)