Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

The most recent articles from: Radiother Oncol March 2004

Radiother Oncol · Mar 2004

Radiation-induced changes in skin type I and III collagen synthesis during and after conventionally fractionated radiotherapy.

To measure local changes of collagen metabolism in irradiated breast skin and systemic changes in serum during and after radiotherapy and correlate these changes with skin thickness, erythema and palpable subcutaneous induration. ⋯ We demonstrated a maximum and elevated levels for PINP and PIIINP skin collagen metabolism determined from SBF during the 2 years' follow-up. Elevated levels of PINP and PIIINP correlated with the thickening of the skin and subcutaneous induration but not with erythema.

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