Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
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Numerous randomized controlled trials and meta-analyses have affirmed that single and multiple fractions of radiotherapy provide equally efficacious outcomes in the palliation of painful, uncomplicated bone metastases (UBM). We aim to determine geographic, temporal and ancillary factors that influence the global patterns of practice in this setting. ⋯ In the last twenty years, there was an overall global reluctance to practice evidence-based medicine by employing single fractions for UBM.
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To evaluate feasibility and toxicity of Hyperfractionated Accelerated Radiotherapy (HART) 1.24Gy b.i.d. followed by chemotherapy for M1-3 Medulloblastoma (MB). The aim of HART was to use hyperfractionation to improve therapeutic ratio combined with acceleration to minimise tumour cell repopulation during radiotherapy (RT). ⋯ HART with or without VCR was well tolerated and may have a place in the multi-modality management of high-risk MB.