Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
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To quantify the impact of tumor-associated resistance factors on local tumor control after split doses of carbon (12C-) ions or photons in an experimental prostate tumor model. ⋯ The response to carbon ion irradiations is much less dependent on biological differences between and within the tumor-sublines. Tumors showing a high resistance against photon treatments, also exhibit the largest RBE for carbon ions. Carbon ions could therefore be of clinical advantage for the treatment of tumors with known resistance factors against photons.