Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
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Robust parameters are needed to predict lymph node metastasis (LNM) in locally advanced cervical cancer patients in order to select optimal treatment regimen. The aim of this study is to utilize radiomics analysis of magnetic resonance imaging (MRI) to improve diagnostic performance of LNM in cervical cancer patients. ⋯ The decision tree, which incorporates radiomics model of T2tumor+peri and c-LN status can be potentially applied in the preoperative prediction of LNM in locally advanced cervical cancer patients.
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The role of bevacizumab (BEV) in the setting of reirradiation (reRT) of malignant glioma recurrences is poorly defined. At our institution, reRT plus BEV was routinely used until its disapproval for glioma treatment by the European Medical Agency. Accordingly, reRT was applied without the addition of BEV since 2017. Here we present for the first time outcome and toxicity profiles of reRT plus BEV and reRT alone for malignant glioma recurrences. ⋯ Concomitant BEV effectively reduces treatment toxicity of reRT and should be reconsidered in future reRT protocols.