European journal of anaesthesiology
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Randomized Controlled Trial Clinical Trial Controlled Clinical Trial
Neuromuscular block: atracurium and vecuronium compared and combined.
The neuromuscular blocking action of atracurium and vecuronium acting separately and in combination have been compared using the evoked EMG of the adductor pollicis muscle. Dose response curves have been drawn for the drugs given separately and found to be nonparallel (P less than 0.05). ⋯ The effect on neuromuscular transmission of a combined medication using equipotent doses of atracurium and vecuronium, determined from the dose response plots, was found to be greater than would be expected by addition of their separate actions. The combination of small doses resulted in significant neuromuscular blockade.