European journal of anaesthesiology
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Randomized Controlled Trial
No adjustment vs. adjustment formula as input weight for propofol target-controlled infusion in morbidly obese patients.
The purpose of this prospective, randomized, double-blind study was to determine the predictive performance of target-controlled infusions of propofol in morbidly obese patients using the 'Marsh' pharmacokinetic parameter set. ⋯ Weight adjustment causes a clinically unacceptable performance bias, which is not corrected when TBW is used as an input to the 'Marsh' model. It is, therefore, advisable to administer propofol to morbidly obese patients by titration to targeted processed-EEG values.
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Randomized Controlled Trial
Lidocaine given intravenously improves conditions for laryngeal mask airway insertion during propofol target-controlled infusion.
Patient response to laryngeal mask airway insertion during propofol induction depends on many factors. Lidocaine has been used to reduce cardiovascular responses, coughing, and bucking induced by tracheal intubation. The aim of this study was to determine the effects of intravenous lidocaine on laryngeal mask airway insertion conditions during the induction of anaesthesia with propofol target-controlled infusion. ⋯ Pretreatment with intravenous lidocaine 1.5 mg kg during induction with propofol target-controlled infusion improves laryngeal mask airway insertion conditions.
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Randomized Controlled Trial Comparative Study
Comparison of etomidate-remifentanil and propofol-remifentanil sedation in patients scheduled for colonoscopy.
The aim of the study was to compare haemodynamic responses, recovery and discharge times, and physician satisfaction of etomidate-remifentanil and propofol-remifentanil combinations in patients undergoing elective colonoscopy. ⋯ Etomidate-remifentanil administration for sedation and analgesia during colonoscopy resulted in more stable haemodynamic responses and shorter recovery and discharge times.
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Randomized Controlled Trial Comparative Study
Auditory function after spinal anaesthesia: the effect of differently designed spinal needles.
Recurrent, bilateral or unilateral, persistent or transient, mild or profound hearing loss has been reported after spinal anaesthesia. We studied the effects of the needle type (Quincke, ballpen, pencil-point spinal needles) on hearing loss after spinal anaesthesia with the use of pure-tone audiometry. ⋯ Because the use of ballpen and pencil-point needles reduces hearing loss after spinal anaesthesia, these needles are preferred.
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Comparative Study Controlled Clinical Trial
PAI-1 gene: pharmacogenetic association of 4G/4G genotype with bleeding after cardiac surgery--pilot study.
To investigate whether the 4G/4G genotype of the PAI-1 gene is associated with bleeding after cardiac surgery and whether it may influence the use of antifibrinolytic drugs. ⋯ The 4G/4G genotype of the PAI-1 gene was associated with less bleeding after cardiac surgery only in the subgroup of patients treated with aprotinin.